Nobel Prize Winners in Medicine That Utilized Animal Models
Year Scientist(s) Animal(s) Used Contribution Made
1960 Burnet, Medawar Rabbit, mouse Understanding of acquired immune tolerance.
1961 von Bekesy Guinea pig Physical mechanism of stimulation in cochlea.
1963 Eccles, Hodgkin, Huxley Cat, frog, squid, crab Ionic involvement in excitation and inhibition in peripheral and central portions of nerve cells.
1964 Bloch, Lynen Rat Regulation of cholesterol and fatty acid metabolism.
1966 Rous, Huggins Rat, rabbit, hen, dog Tumor inducing viruses and hormonal treatment of cancer.
1967 Hartline, Granit, Wald Chicken, rabbit, fish, crab Primary physiological and chemical processes of vision.
1968 Holley, Khorana, Nirenberg Rat Interpretation of genetic code and its role in protein synthesis.
1970 Katz, von Euler, Axelrod Cat, rat Mechanisms of storage and release of nerve transmitters.
1971 Sutherland Mammalian liver Mechanism of the actions of hormones.
1972 Edelman, Porter Guinea pig, rabbit Chemical structure and nature of antibodies.
1973 von Frisch, Lorenz, Tinbergen Bird, bee Organization of social and individual behavior patterns in animals.
1974 de Duve, Palade, Claude Chicken, guinea pig, rat Structural and functional organization of cells.
1975 Baltimore, Dulbecco, Temin Monkey, horse, chicken, mouse Interaction between tumor viruses and genetic material.
1976 Blumberg, Gajusek Chimpanzee Slow viruses and new mechanism for dissemination of diseases.
1977 Guillemin, Schally, Yalow Sheep, swine Role of hypothalmic hormones in body.
1979 Cormack, Hounsfield Pig Development of computer-assisted tomography (CAT scan).
1980 Benacerraf, Dausset, Snell Mouse, guinea pig Identification of histocompatibility antigens and mechanism of action.
1981 Sperry, Hubel, Wiesel Cat, monkey Processing of visual information by the brain.
1982 Bergstrom, Samuelson, Vane Ram, rabbit, guinea pig Discovery of prostaglandins.
1984 Milstein, Kohler, Jerne Mouse Technique of monochlonal antibody synthesis.
1986 Levi-Montalcini, Cohen Mouse, chick, snake Nerve growth factor and epidermal growth factor.
1987 Tonegawa Mouse embryo Basic principles of antibody synthesis.
1989 Varmus, Bishop Chicken Cellular origin of retroviral oncogenes.
1990 Marray, Thomas Dogs Organ transplantation techniques.
1991 Neher, Sakmann Frogs Chemical communication between cells.

1992

Fischer, Krebs Rabbit Regulatory mechanism in cells

1995

Lewis, Wieschaus, Nusslein-Volhard Fruit fly Genetic control of early structural development

1996

Doherty, Zinkernagel Mouse Immune-system detection of virus-infected cells

1997

Prusiner* Hamster, mouse Discovery and characterization of prions

1998

Furchgott, Ignarro, Murad Rabbit Nitric oxide as signaling molecule in cardiovascular system

1999

Blobel Various animal cells Proteins have intrinsic signals that govern their transport and localization in the cell.

2000

Carlsson, Greengard, Kandel Mice, Guinea pigs, sea slugs Signal transduction in the nervous system
2002
Brenner, Horvitz, Sulston Roundworm Genetic regulation of organ development and programmed cell death
2002
Brenner, Horvitz, Sulston Roundworm Genetic regulation of organ development and programmed cell death
2004
Axel, Buck Mice Odorant receptors and the organization of the olfactory system

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